We are pleased to share a recent publication in Cell Death & Disease (Nature Portfolio) led by Dr Nithya Balasundaramand Prof. Vikram Mathews from Christian Medical College, Vellore. The study explores a new way to treat acute myeloid leukemia (AML) by targeting the energy systems that leukemia cells rely on to survive.

🔗 Read the article: https://lnkd.in/e6pf_NDi

AML is an aggressive blood cancer, and treatment options have changed little over the past few decades. This research shows that AML cells—especially the cells responsible for disease relapse—depend heavily on a specific energy pathway within their mitochondria. By disrupting this pathway, leukemia cells may be more effectively targeted while sparing healthy cells.

Importantly, the study highlights the potential of repurposing the antimalarial drug artesunate as an add-on to existing AML treatments. These findings are now being taken forward into early-phase clinical trials.

This work also reflects strong international collaboration, including earlier research carried out at City St George’s, University of London, and supports future clinical partnerships between India and Malaysia through the International Affordable Diagnostics & Therapeutics Alliance (IA-DATA).